Table 1.
Cell line genetic abnormalities.
| Cell Line | MYCN Status | 11q Status (Genes Deleted) | p53 Status | Reference |
|---|---|---|---|---|
| SHSY5Y | Non-amp | No deletion | WT | [34] |
| SKNAS | Non-amp | Deletion (MRE11, ATM, CHEK1, H2AFX) | Mutant Deletion of intron9/exon 10 | [35,36] |
| NGP | Amp | Deletion (ATM, CHEK1, H2AFX) | WT | [36] |
| N20_R1 | Amp | Deletion ** (ATM, CHEK1, H2AFX) | Mutant P98H P152T | [37] |
| NMB * | Amp | Deletion (MRE11, ATM, CHEK1, H2AFX) | Mutant G245S | [36,38] |
| IMR32 | Amp | Deletion (ATM, CHEK1, H2AFX) ATM mutant V2716A | WT | [39,40] |
| IMR32/Kat100 (Kat100) | Amp | Unknown | Mutant C135F | [41] |
| IGRN91 | Amp | No deletion | Mutant Duplication of exons 7–9 | [42,43] |
| SJNB1 * | Non-amp | Deletion (MRE11, ATM, CHEK1, H2AFX) | WT | [36] |
| GIMEN | Non-amp | Deletion (MRE11, ATM, CHEK1, H2AFX) | WT | [36] |
Amp: amplified, Non-amp: non-amplified, WT: wild type; * cell line is near tetraploid [44], Chr11 LOH; ** derived from NGP, assume same.