Table 2.
Summary of VE-821 and olaparib single agent sensitivity.
| Cell Line | MYCN Status | 11q Status (Genes Deleted) | p53 Status | VE-821 GI50 (μM) | VE-821 LC50 (μM) | Olaparib GI50 (μM) | Olaparib LC50 (μM) |
|---|---|---|---|---|---|---|---|
| SHSY5Y | Non-amp | No deletion | WT | 7.11 | 1.54 | 5.38 | 1.40 |
| SKNAS | Non-amp | Deletion (MRE11, ATM, CHEK1, H2AFX) | Mut | >20 | 0.81 | >30 | 1.31 |
| NGP | Amp | Deletion (ATM, CHEK1, H2AFX) | WT | 1.62 | 0.93 | 1.35 | 1.20 |
| N20_R1 | Amp | Deletion (ATM, CHEK1, H2AFX) | Mut | 8.29 | 0.93 | 1.64 | 0.68 |
| NMB | Amp | Deletion (MRE11, ATM, CHEK1, H2AFX) | Mut | 2.36 | 1.91 | 3.88 | 0.92 |
| IMR32 | Amp | Deletion (ATM, CHEK1, H2AFX) ATM mutant V2716A | WT | 0.66 | 0.90 | 1.81 | 0.63 |
| Kat100 | Amp | Unknown | Mut | 1.88 | 1.50 | >30 | 1.55 |
| IGRN91 | Amp | No deletion | Mut | 3.04 | 1.03 | >30 | 0.74 |
| SJNB1 | Non-amp | Deletion (MRE11, ATM, CHEK1, H2AFX) | WT | 6.30 | 1.99 | 4.70 | 0.75 |
| GIMEN | Non-amp | Deletion (MRE11, ATM, CHEK1, H2AFX) | WT | >20 | 0.87 | 12.25 | 0.37 |