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. 2020 May 13;22(8):294–310. doi: 10.1016/j.neo.2020.04.005

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© 2020 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 5 — A panel of NSCLC cell lines exhibits differential dependencies on FOXA1. (A) Knockdown of FOXA1 in a panel of cell lines was verified by Q-RTPCR in all cell lines. RQ = relative quantification, internally normalized to GAPDH, calculated from three technical replicates. (B) Proliferation rates after knockdown of FOXA1 as measured by MTS assay, calculated from at least three technical replicates. RP = relative proliferation, normalized to non-targeting control shRNA (shNTC). (C) Representative colony formation assays in a panel of NSCLC cell lines with knockdown of FOXA1. (D) Quantitation of clonogenicity after knockdown of FOXA1. RC = relative clonogenicity, normalized to shNTC, calculated from at least three technical replicates. (E) Relative clonogenicity compared to FOXA1 copy number and FOXA1 Illumina array-based mRNA expression levels.