Table 1.
Types and features of human adenoviruses.
| Species | Serotype | Identified Receptor(s) for Members of this Species | Tropism |
|---|---|---|---|
| A | 12, 18, 31, 61 | CAR | Cryptic (enteric, respiratory) |
| B | 3, 7, 11, 14, 16, 21, 34, 35, 50, 55, 66, 68, 76–79 | CD46, DSG2, CD80, CD86 | Respiratory, renal, ocular |
| C | 1, 2, 5, 6, 57, 89 | CAR, VCAM-1, HSPG, MHC1-a2, SR | Respiratory, ocular, lymphoid, hepatic |
| D | 8–10, 13, 15, 17, 19, 20, 22–30, 32, 33, 36–39, 42–49, 51, 53, 54, 56, 58–60, 62–65, 67, 69–75, 80–88, 90–103 | SA, CD46, CAR | Ocular, enteric |
| E | 4 | CAR | Respiratory, ocular |
| F | 40, 41 | CAR | Enteric |
| G | 52 | CAR, SA | Enteric |
Note 1: CAR, coxsackievirus- and adenovirus receptor. DSG2, desmoglein-2. MHC1-a2, major histocompatibility complex-a2. SA, sialic acid. SR, scavenger receptor. VCAM-1, vascular cell adhesion molecule-1. HSPG, heparin sulfate proteoglycans.