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The regulation of Rho GTPases activation. Most Rho GTPases are regulated by RhoGEFs, RhoGAPs, and RhoGDIs. Rho GTPases are also regulated by post-translational modification, including phosphorylation, sumoylation, and ubiquitination. Post-translational modifications (PTMs) of Rho GTPases regulate their intracellular localization, stability, and ability to signal to downstream effector.
