Table 2.
Selected inhibitors of Rho GTPase signaling.
| Drug Name | Target Protein | Mechanism | Refs |
|---|---|---|---|
| Rhosin | RhoA | Inhibit GEF biding | [129] |
| Y16 | LARG | Inhibit RhoA binding | [130] |
| NSC23766 | Rac1 | Inhibit GEF binding | [132] |
| EHop-016 | Rac1 | Derivative of NSC23766 | [133] |
| CASIN | Cdc42 | Inhibit GEF binding | [134,135] |
| ZCL278 | Cdc42 | Inhibit GEF binding | [136,137] |
| Y-27632 | ROCK | Compete with ATP | [140] |
| Wf-536 | ROCK | Derivative of Y-27632 | [144] |
| Fasudil | ROCK | Compete with ATP | [141] |
| RKI-1447 | ROCK | Compete with ATP | [144] |
| AT13148 | ROCK | Compete with ATP | [146] |
| K252 | PAK | Compete with ATP | [151] |
| OSU-03012 | PAK | Compete with ATP | [152] |
| PF-3758309 | PAK | Compete with ATP | [153] |
| FRAX597 | PAK | Compete with ATP | [147] |
| IPA-3 | PAK | Promote auto-inhibited conformation | [148] |