Table A2.
Ingenuity Upstream Regulator, Diseases and Functions and Pathway Analyses of sEV protein features identified in two or more adenocarcinoma panel (LUAD and PDAC) cell lines with SA ≥ 2.
| A. Top-ranked statistically enriched Upstream Regulators. | |||
|---|---|---|---|
| Upstream Regulator | Molecule Type | p-Value | Mechanistic Network |
| TP53 | transcription regulator | 1.69 × 10−77 | 1105 (22) |
| MYC | transcription regulator | 1.13 × 10−70 | 1312 (20) |
| MAPT | other | 1.26 × 10−63 | 1145 (18) |
| TGFB1 | growth factor | 5.91 × 10−56 | 1169 (20) |
| MYCN | transcription regulator | 1.07 × 10−50 | 1063 (18) |
| KRAS | enzyme | 2.93 × 10−49 | 1119 (19) |
| B. Top ten statistically enriched IPA Diseases and Functions annotations. | |||
| Category | Diseases or Functions Annotation | p-Value | #Molecules |
| Cancer, Organismal Injury & Abnormalities | Nonhematologic malignant neoplasm | 2.76 × 10−133 | 2431 |
| Cancer, Organismal Injury & Abnormalities | Non-hematological solid tumor | 4.36 × 10−133 | 2436 |
| Cancer, Organismal Injury & Abnormalities | Epithelial neoplasm | 2.79 × 10−131 | 2410 |
| Cancer, Organismal Injury & Abnormalities | Carcinoma | 4.72 × 10−131 | 2407 |
| Cancer, Organismal Injury & Abnormalities | Non−melanoma solid tumor | 4.72 × 10−131 | 2421 |
| Cancer, Organismal Injury & Abnormalities | Tumorigenesis of tissue | 4.25 × 10−130 | 2414 |
| Cancer, Organismal Injury & Abnormalities | Cancer | 3.96 × 10−123 | 2457 |
| Cancer, Organismal Injury & Abnormalities | Malignant solid tumor | 2.43 × 10−120 | 2445 |
| Cancer, Organismal Injury & Abnormalities | Extracranial solid tumor | 9.08 × 10−119 | 2442 |
| Cancer, Organismal Injury & Abnormalities | Solid tumor | 1.03 × 10−118 | 2452 |
| C. Top ten statistically enriched IPA Cancer Signaling Canonical Pathways. | |||
| Ingenuity Canonical Pathway | p-Value | Ratio | #Molecules |
| Breast Cancer Regulation by Stathmin1 | 5.01 × 10−32 | 0.440 | 88/200 |
| ERK/MAPK Signaling | 5.01 × 10−22 | 0.378 | 73/193 |
| Role of Tissue Factor in Cancer | 6.31 × 10−19 | 0.436 | 51/117 |
| FAK Signaling | 1.26 × 10−18 | 0.474 | 45/95 |
| PI3K/AKT Signaling | 2.00 × 10−17 | 0.356 | 62/174 |
| Molecular Mechanisms of Cancer | 1.58 × 10−16 | 0.261 | 102/391 |
| Telomerase Signaling | 3.16 × 10−13 | 0.383 | 41/107 |
| Glioma Invasiveness Signaling | 3.98 × 10−13 | 0.446 | 37/74 |
| BAG2 Signaling Pathway | 1.58 × 10−12 | 0.558 | 24/43 |
| PTEN Signaling | 3.98 × 10−11 | 0.333 | 42/126 |