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. 2020 May 21;12(5):1305. doi: 10.3390/cancers12051305

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Difference in migration mode and FAK activation between PANC-1 and BxPC-3 cells in a collagen matrix. (A) Time-lapse images of cell migration under PSC co-culture conditions, showing differential migration modes. Direction of cell migration is indicated by arrows. Scale bar: 100 µm. (B) Increased number of invadopodia (arrowhead) in PANC-1 TSs under PSC co-culture conditions. Scale bar: 100 µm. (C) Comparison of podium morphology and expression of pFAK at the leading edge of the protrusion between PANC-1 and BxPC-3 cells under co-culture conditions. A: amoeboid mode. M: mesenchymal mode. White arrow: spike-like filopodia. Scale bar: 20 µm. Three fields covering 80% of the effective area in each channel were imaged per experiment and subjected to analysis. Data were obtained from three separate independent experiments. *** p < 0.005.