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Inhibitory effects (IC50 = μM) of compounds 1–5 on the overproduction of NO and prostaglandin E2 (PGE2) in lipopolysaccharide (LPS)-stimulated cells.
| Compounds | NO Inhibitory Effects a | PGE2 Inhibitory Effects a | ||
|---|---|---|---|---|
| BV2 Cells | RAW264.7 Cells | BV2 Cells | RAW264.7 Cells | |
| 1 | >80 | >80 | >80 | 50.2 ± 2.5 |
| 2 | 2.7 ± 0.1 | 4.7 ± 0.2 | 3.2 ± 0.2 | 4.1 ± 0.1 |
| 3 | >80 | >80 | >80 | 53.4 ± 2.7 |
| 4 | 28.1 ± 1.4 | 41.5 ± 2.1 | 25.2 ± 1.3 | 30.0 ± 1.5 |
| 5 | 10.6 ± 0.5 | 40.1 ± 2.0 | 32.3 ± 1.6 | >80 |
a Values present mean ± SD of triplicate experiments.
