Most important sequence types (STs) of Streptococcus suis serotype 2 as determined by multilocus sequence typing (MLST): ST1 serotype 2 strains are mostly associated with disease in both pigs (where data are available) and humans in Europe, Asia, Africa, and South America. The situation is different in North America, where fewer clinical ST1 cases of infection in pigs and only one human ST1 case has been described. ST7, a single locus variant of ST1, is endemic to mainland China. Interestingly, Japan and Thailand are the only countries reporting ST28 human cases [2]. “?” means no data available from swine clinical cases.