Figure 3.

Heatmaps of ex vivo drug response associated gene expression patterns of pediatric AML blasts. Expression of probes was correlated to ex vivo drug response LC₅₀ values using the Spearman’s Rank method. Probes were selected based on a p-value < 0.001. Probes (rows) were clustered using mean linkage, and samples were ordered according to ex vivo drug LC₅₀ towards (A) Ara C, (B) DNR, (C) 2-CdA, and (D) VP16 LC₅₀. Bar plots represent LC₅₀ (μM) per patient. Black blocks underneath heatmaps indicate presence of recurrent mutations in samples.