Table A2.
Median LC50 (µM) of patient samples in the discovery cohort per molecular group. Visualization and full mutation group-comparison results can be found in Supplementary Figure S1. No statistical differences in LC50 values were observed between genetic (p > 0.1, unpaired t-test) or karyotype groups (p > 0.063, Kruskal-Wallis).
| Category | Molecular Aberration | n | Ara C | DNR | 2-CdA | VP16 |
|---|---|---|---|---|---|---|
| Total | 38–73 | 1.48 | 0.33 | 0.07 | 4.55 | |
| Cytogenetics | ||||||
| Normal | 16 | 1.09 | 0.30 | 0.08 | 4.51 | |
| t(8;21) | 7 | 1.54 | 0.33 | 0.08 | 11.05 | |
| MLL rearranged | 19 | 1.23 | 0.24 | 0.01 | 3.62 | |
| Abnormal 16 | 8 | 1.37 | 0.68 | 0.08 | 22.48 | |
| -7/7q- | 1 | 2.09 | 0.47 | 0.13 | 5.12 | |
| Tris8 | 2 | 1.14 | 0.52 | 0.08 | 0.00 | |
| Other | 14 | 1.37 | 0.26 | 0.06 | 4.25 | |
| Gene mutations | ||||||
| FLT3/ITD | 15 | 1.07 | 0.34 | 0.08 | 4.51 | |
| NPM1 | 6 | 1.07 | 0.27 | 0.21 | 4.51 | |
| CEBPA | 5 | 0.79 | 0.41 | 0.01 | 3.99 | |
| WT1 | 5 | 0.79 | 0.42 | 0.03 | 4.37 | |
| NRAS/KRAS | 15 | 1.29 | 0.43 | 0.09 | 13.08 | |
| CKIT | 9 | 1.54 | 0.36 | 0.08 | 15.85 |