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. 2020 May 6;12(5):1173. doi: 10.3390/cancers12051173

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Influence of ECM protein and fibroblast composition on MMPs secretion. (a) Schematic of the process. Metalloproteinases (MMP) concentration for the different microenvironments was determined via a multiplex bead-based ELISA. (b–d) MMPs fold change in co-culture with HMFs (purple bars) and CAFs (red) within a collagen matrix (solid bar) and a fibronectin-rich matrix (striped bar) fibroblast monoculture showed in solid black. (b) MMP-2-fold change. (c) MMP-3-fold change. (d) MMP-9-fold change. (e–g) MMP fold increase in the fibronectin-rich matrix compared to the collagen-only matrix for the co-culture with HMFs (patterned purple) and CAFs (patterned red) (e) MMP-2- (f) MMP-3- (g) MMP-9. Bars represent average ± SD, n = at least four individual devices. * p ≤ 0.05, ** p ≤ 0.01, *** p < 0.001.