Figure A3.

Distribution of root-mean-square deviation (RMSD) for homology models compared with their corresponding experimental structures, after refinement involving the rejection of structural alignment outliers. Each experimental structure present in the library was modeled by selecting from all other templates in the library. The top three models for each structure based on combined MODELLER DOPE and PROCHECK G-FACTOR scores are considered here. (A) Distribution mean = 1.55 Å, standard deviation = 0.92 Å. (B) Distribution mean = 1.17 Å, standard deviation = 0.67 Å.