Table 2.
List of sequences containing six cysteines in order of interest for experimental characterization, based on the degree (sequence coverage) in alignment graphs (cf. Figure 2). Name or names of sequences are taken from the Conoserver database [40]. Multiple names for the same sequence indicate the same sequence is produced by different species or has different post-translational modifications. Node degree corresponds to the number of sequences with pairwise alignments that are long enough and have a high enough percent identity to be homology modeled with the given sequence as a template. Cysteines are highlighted in red to guide the eye. We note in the fourth column the pharmacological family, although it is unknown for the majority of sequences, as it requires a separate experimental determination in most cases.
| Sequence | Name(s) | Degree | Pharm. Fam. |
|---|---|---|---|
| LPPCCSLNLRLCPAPACKYKPCCKS | RIIIJ 6-11 | 29 | Unknown |
| QKGLVPSVITTCCGYDPGTMCPPCRCTNSCPKKPKKP | S4.4 | 28 | Unknown |
| QPWLVPSKITNCCGYNTMEMCPTCMCTYSCRPKKKKP | Mn4.2 | 27 | Unknown |
| DDECEPPGDFCGFFKIGPPCCSGWCFLWCA | MaIr137, G6.2 | 20 | Unknown |
| DCVAGGHFCGFPKIGGPCCSGWCFFVCA | Vn6.8 | 20 | Unknown |
| VCREKGQGCTNTALCCPGLECEGQSQGGLCVDN | Mi010 | 20 | Unknown |
| ECREQSQGCTNTSPPCCSGLRCSGQSQGGVCISN | CaHr91 | 17 | Unknown |
| TVDEACNEYCEERNKNCCGRTDGEPVCAQACL | Vi6.7 | 15 | Unknown |
| ECTRSGGACYSHNQCCDDFCSTATSTCV | Eb6.22 | 15 | Unknown |
| GCTPPGGACGGHAHCCSQSCNILASTCNA | ABVIC | 15 | Unknown |
| TVGEECNEYCEQRNKNCCGKTNGEPVCAQACL | Tr7.4 | 15 | Unknown |
| TATEECEEYCEDEEKTCCGEEDGEPVCARFCL | Ar6.24 | 14 | Unknown |
| EACYNAGTFCGIKPGLCCSAICLSFVCISFDLIDVFSSP | M6.2 | 13 | Unknown |
| TTEECHEYCEDQNKNCCGLTDGEPRCAGMCL | Tr7.3 | 13 | Unknown |
| MTMGCTHPGGACGGHYHCCSQSCNTAANSCN | MIL3-b (partial) | 12 | Unknown |
| VPEECEESCEEEEKTCCGLENGQPFCSRICW | Ar6.28 | 12 | Unknown |
| DECYPPGTFCGIKPGLCCSERCFPFVCLSLEF | Ac6.2 | 12 | Unknown |
| CLDAGEVCDIFFPTCCGYCILLFCA | TxO1 | 11 | omega |
| DCTPPDGACGFHYHCCSKFCITISSTCN | MIL2-a | 11 | Unknown |
| CIDGGEICDIFFPNCCSGWCIILVCA | Mr6.8 | 11 | Unknown |
| TTAESWWEGECLGWSNGCTHPSDCCSNYCKGIYCDL | Mr6.16 | 11 | Unknown |
| GCTHPGGACGGHHHCCSLFCNTAANACN | MIL3-f | 11 | Unknown |
| CLGSGETCWLDSSCCSFSCTNNVCF | Vn6.15 | 11 | Unknown |
| CLDAGEMCDLFNSKCCSGWCIILFCA | Mr6.1 | 10 | Unknown |
| SCGEEGEGCYTRPCCPGLKCIGTAHGGLCREE | Pu6.7 | 10 | Unknown |
| GCLEVDYFCGIPFVNNGLCCSGNCVFVCTPQ | Pn6.7 | 10 | Unknown |
| SIAGRTTTEECDEYCEDLNKNCCGLSNGEPVCATACL | Ts6.7 | 10 | Unknown |
| DGCYNAGTFCGIRPGLCCSEFCFLWCITFVDS | MVIA, Cn6.1 | 10 | delta |
| NCCNGGCSSKWCRDHARCC | SIIIA[del1] | 9 | Unknown |
| KTTAESWWEGECYGWWTSCSSPEQC– | |||
| CSLNCENIYCRAW | TsMEKL-03 | 8 | Unknown |
| RHGCCKGPKGCSSRECRPQHCC | TIIIA | 8 | mu |
| DCGEQGQGCYTRPCCPGLHCAAGATGGGSCQP | Conotoxin-1 | 8 | Unknown |
| CLAGSAPCEFHRGYTCCSGHCLIWVCA | Cal6.1d | 8 | Unknown |
| KTTAESWWEGECRTWYAPCNFPSQC– | |||
| CSEVCSSKTGRCLTW | Vn6.5 | 7 | Unknown |
| CRPPGMVCGFPKPGPYCCSGWCFAVCLPV | MaIr193 | 7 | Unknown |
| CTPGGEACDATTNCCFLTCNLATNKCRSPNFP | ABVIL | 7 | Unknown |
| WWEGECRGWSNGCTTNSDCCSNNCDGTFCKLW | Vn6.3 | 7 | Unknown |
| WWWGGCTWWFGRCSTDSECCSNSCDQTYC– | |||
| ELYRFPSRY | Vc6.26 | 7 | Unknown |
| YECYSTGTFCGINGGLCCSNLCLFFVCLTFS | CnVIA, St6.2 | 7 | delta |
| CCSRDCWVCIPCCPNGSA | Lv3-IP01 | 7 | Unknown |
| VCVDGGTFCGFPKIGGPCCSGWCIFVCL | Ar6.2 | 6 | Unknown |
| ECIEGSEPCEVFRPYTCCSGHCIIFVCA | Cal6.1h | 6 | Unknown |
| CCSQDCWVCIPCCPN | Eu3.2 | 6 | Unknown |
| CCSQDCSVCIPCCPN | Co3-IP02, Ts3-IP07, Vr3-IP08, Rt3-IP03, Ca3-IP02, Ec3-IP03 | 6 | Unknown |
| CYDSGTSCNTGNQCCSGWCIFVSCL | Tx6.3 | 6 | Unknown |
| CTVDSDFCDPDNHDCCSGRCIDEGGSGVCAIVPVLN | Ar6.19 | 6 | Unknown |
| FPCNPGGCACRPLDSYSYTCQSPSSSTANCEGNECVS– | |||
| EADW | Cl9.4 | 6 | Unknown |
| GPPCCLYGSCRPFPGCSSASCCRK | PIIIF [Y17S,N18S,L20S] | 5 | Unknown |
| DCQEKWDYCPVPFLGSRYCCDGFICPSFFCA | Da6.6, Tx6.6 | 5 | Unknown |
| CCGVPNAACHPCVCNNTC | OIVA [K15N] | 5 | Unknown |
| CTPRNGYCYYRYFCCSRACNLTIKRCL | Ml6.2 | 5 | Unknown |
| CCSQDCRVCIPCCPN | Ts3.1 | 5 | Unknown |
| QCTPVGGSCSRHYHCCSLYCNKNIGQCLATSYP | Ar6.17 | 5 | Unknown |
| CLNDGDDCDTGDDCCSGLCIFDEYFSYCDDSDP– | |||
| YYDDYDEYYY | Mi029 | 5 | Unknown |
| SCGNLHESCSAHRCCPGLKCIGTAHGGLCRE | Pu6.15 (partial) | 5 | Unknown |
| VKPCSEEGQLCDPLSQNCCRGWHCVLVSCV | Da6.2 | 5 | Unknown |
| FAVIFTCTPPGSHCTGHSDCCSDFCSTMSDVCQ | Co6.1 | 4 | Unknown |
| WWDGECRLWSNGCRKHKECCSNHCKGIYCDIW | VeG52 | 4 | Unknown |
| CTPCGPDLCCEPGTTCDTVLHHTRFGEPSCSY | Fla6.16 | 4 | Unknown |
| CCGKPNAACHPCVCNGSCS | G4.1 | 4 | Unknown |
| MGYILPALSQQTCCVRPWCDGACDCCVDS | Co3-D01 | 4 | Unknown |
| MKLMLSALRQQECCKPSTCDGGCYHCC | Lv3-YH04 | 4 | Unknown |
| SCGNLHESCSAHRCCPGLMCFTLPTPICIW | Pu6.17 | 4 | Unknown |
| CIPQFDPCDMVRHTCCKGLCVLIACSKTA | Pn6.3 | 4 | Unknown |
| STSCMEAGSYCGSTTRICCGYCAYFGKKCIDYPSN | SO5 | 4 | omega |
| GGCTPCGPNLCCSEEFRCGTSTHHQTYGEPACLSY | Ca6.2 | 4 | Unknown |
| CLGFGEACLMLYSDCCSYCVALVCL | Ep6.1 | 4 | Unknown |
| CIEQFDPCEMIRHTCCVGVCFLMACI | King-Kong 1 | 4 | Unknown |
| TCSPAGEVCTSKSPCCTGFLCTHIGGMCHH | LvVIA 2 | 4 | Unknown |
| CTPSGGACYVASTCCSNACNLNSNKCV | M1 | 4 | Unknown |
| CCGVPNAACHPCVCTGKC | PeIVA | 4 | alpha |
| ATDCIEAGNYCGPTVMKICCGFCSPFSKICMNYPQN | Ac6.5 | 4 | Unknown |
| GCTPRNGACGYHSHCCSNFCHTWANVCL | LvVID | 3 | Unknown |
| DVCELPFEEGPCFAAIRVYAYNAKTGDCEQLTY– | |||
| GGCEGNGNRFATLEDCDNACARY | Cal9.1d | 3 | Unknown |
| KFCCDSNWCHISDCECCY | Tx3h | 3 | Unknown |
| GCGYLGEPCCVAPKRAYCHGDLECNSVAMCVN | Mr2 | 3 | Unknown |
| ECTPPEGACNHPSHCCEDFCDRGRNRCM | At6.7 | 3 | Unknown |
| WWEGDCTDWLGSCSSPSECCYDNCETYCTLW | Lt7b | 3 | Unknown |
| CRSSGSPCGVTSICCGRCYRGKCT | SVIA | 3 | omega |
| CKAESEACNIITQNCCDGKCLFFCIQIPE | Pn6.5 | 3 | Unknown |
| CKSPGTPCSRTMRDCCTSCLSYSKKCR | G6.12 | 3 | Unknown |
| CTPPSGYCYHPYYCCSRACNLTRKRCL | At6.2 | 3 | Unknown |
| PCKTPGRKCFPHQKDCCGRACIITICP | P2a | 3 | Unknown |
| CVPYEGPCNWLTQNCCDELCVFFCL | Gm6.3 | 3 | Unknown |
| SKQCCHLPACRFGCTPCCW | Mr3.4 | 3 | Unknown |
| CCKYGWTCWLGCSPCGC | PnIVB | 2 | mu |
| EIILHALGTRCCSWDVCDHPSCTCC | Vr3-T05 | 2 | Unknown |
| CNNRGGGCSQHPHCCSGTCNKTFGVCL | VxVIA, MgJ42 | 2 | Unknown |
| CAGIGSFCGLPGLVDCCSGRCFIVCLP | Bt6.4, ErVIA | 2 | Unknown |
| CCHWNWCDHLCSCCGS | Mr3.8 | 2 | Unknown |
| CCQAACSPWLCLPCC | Eu3.3, Bt3.3 | 2 | Unknown |
| CIPFLHPCTFFFPDCCNSICAQFICL | VcVIC | 2 | Unknown |
| CTQSSEFCDVIDPDCCSGVCMAFFCI | Vc6.40 | 2 | Unknown |
| CTVNGVVCDPGNHNCCSGSCLDDEDTPVCGIHV– | |||
| EIQHVHMLS | Pu6.23 | 2 | Unknown |
| CCDDSECDYSCWPCCMF | Gm3-WP04 | 2 | Unknown |
| DAINVAPGTSITRTETDQECIDTCKQEDKKCCG– | |||
| RSNGVPTCAKICL | Di6.11 | 2 | Unknown |
| CLAPQRWCSMHDDSLHDDNCCKTCIILWCS | Pu6.20 | 2 | Unknown |
| CIVGTPCHVCRSQSKSCNGWLGKQRYCGYC | Im9.11 | 2 | Unknown |
| CCDRPCSIGCVPCCLP | Ca3-VP01, Cp3-VP05 | 2 | Unknown |
| YWTECCGRIGPHCSRCICPGVVCPKR | Bu25 | 2 | Unknown |
| WFGHEECTYWLGPCEVDDTCCSASCESKFCGLW | RVIIA | 2 | Unknown |
| QCEDVWMPCTSSHWECCSLDCEMYCTQI | Mr6.29 | 2 | Unknown |
| QCPYCVVHCCPPSYCQASGCRPP | Vc7.4 | 2 | Unknown |
| QGCCNVPNGCSGRWCRDHAQCC | MIIIA | 2 | mu |
| TCSSSSDCPTGQECCPDKLDEPEGSCANECIIT | Pu6.37 | 2 | Unknown |
| SCSDDWQYCEYPHDCCSWSCDVVCS | Vc6.12 | 2 | Unknown |
| TCNTPTRYCTLHRHCCSLHCHKTIHACA | Pu6.30 | 2 | Unknown |
| TTSTRKCKGPLVFCPENHECCSKFCDFIDIPLRYCSTP | Br7.9 | 2 | Unknown |
| MTKHCTPPEVGCLFAYECCSKICWRPRCYPS | ABVIE | 2 | Unknown |
| VCCPFGGCHELCLCCD | MrIIIF | 2 | Unknown |
| RCCISPACHDDCICCIT | S3-I05 | 2 | Unknown |
| RCCISPACHEECYCCQ | S3-Y01 | 2 | Unknown |
| VSIWFCASRTCSTPADCNPCTCESGVCVDWL | Lt9a variant 2 | 2 | Unknown |
| QCLPPLSLCTMDDDECCDDCILFLCLVTS | Ar6.5 | 2 | Unknown |
| STDDCSTAGCKNVPCCEGLVCTGPSQGPVCQPLA | Vn6.18 | 2 | Unknown |
| GCCDPQWCDAGCYDGCC | Qc3-YDG01 | 2 | Unknown |
| GCWLCLGPNACCRGSVCHDYCPS | Cal6.4c | 2 | Unknown |
| GCSDFGSDCVPATHNCCSGECFGFEDFGLCT | Pu6.25 | 2 | Unknown |
| STDCNGVPCQFGCCVTINGNDECRELDC | Mr6.23 | 2 | Unknown |
| RCCTWQECDGNCHCCQ | Cp3-H02 | 2 | Unknown |
| RCCVHPACHDDCICCIT | Bt3-I03, Vx3-I03 | 2 | Unknown |
| WWGENDCSWTGPCTVNAECCLGVCDETC | Tx7.31 | 2 | Unknown |
| GCCHPSTCHVRKGCSRCCS | Tx3g, Vt3-SR01 | 2 | Unknown |
| SSDEECVGLSGYCGPWNNPPCCSWWECEVYCAVPGPSF | Mi034 | 2 | Unknown |
| SCCNAGFCRFGCTPCCY | Tx3e, Vt3-TP01, Ec3-TP01-2 | 2 | Unknown |
| TCDPYYCNDGKVCCPEYPTCGDSTGKLICVRVTD | Im6.7 | 1 | Unknown |
| TCLEIGEFCGKPMMVGSLCCSPGWCFFICVG | Pc6b | 1 | Unknown |
| CGGYSTYCEVDSECCSDNCVRSYCTLF | TxVIIA | 1 | gamma |
| GCCCNPACGPNYGCGTSCSRPSEP | S1.7 | 1 | Unknown |
| TRGCKSKGSFCWNGIECCGGNCFFACVY | Cl6.6b | 1 | Unknown |
| CFESWVACESPKRCCSHVCLFVCT | Pn6.6 | 1 | Unknown |
| WREGSCTSWLATCTDASQCCTGVCYKRAYCALWE | TxMEKL-022/TxMEKL-021 | 1 | Unknown |
| YCSDSGGWCGLDPELCCNSSCFVLC | Cl6.8 | 1 | Unknown |
| YCSDDWQPCSHFYDCCKWSCNNGYCP | Vc6.25 | 1 | Unknown |
| CCDDSECSYSCWPCCY | TxMMSK-02, Cp3-WP03, Vr3-WP04, S3-WP01, Rt3-WP01 | 1 | Unknown |
| WRVDSECISFWGSCTVDADCCFNSCDETYGYC | Tx7.30 | 1 | Unknown |
| CCDWPCTIGCVPCCLP | TsMMSK-021 | 1 | Unknown |
| CCFWPMCRGCDCCYL | Lv3-D02 | 1 | Unknown |
| CCGPTACLAGCKPCCY | Tx3-KP03 | 1 | Unknown |
| CESYGKPCGIYNDCCNACDPAKKTCT | Conotoxin-3 | 1 | Unknown |
| VQPSECKLPAAKGPCKGKYRKVYFNNFKKQCRM– | |||
| FTYGGCGGNGNKFRNAKECYHKCAYGV | conkunitzin-G1 | 1 | Unknown |
| VCCSFGSCDSLCQCCD | Mr3.16 | 1 | Unknown |
| CCLWPECGGCVCCYL | Lv3-V02 | 1 | Unknown |
| TRGCKTKGTWCWASRECCLKDCLFVCVY | Cl6.10 | 1 | Unknown |
| CCSVSICQSPPVCECCA | S3-E03 | 1 | Unknown |
| CCVVCNAGCSGNCCS | Ts3-SGN01 | 1 | Unknown |
| SCSGSGYGCKNTPCCAGLTCRGPRQGPICL | Vn6.16 | 1 | Unknown |
| RCCIWPECGSCVCCL | Cp3-V08 | 1 | Unknown |
| SCGNLHEMCNYHLPCCRPWRCRASRTGTR– | |||
| CLNKPRYRPV | Pu6.13 | 1 | Unknown |
| RDCRPVGQYCGIPYEHNWRCCSQLCAIICVS | PuIA | 1 | omega |
| GCCGSFACRFGCVPCCV | MrIIIA | 1 | Unknown |
| GCCHLLACRMGCTPCCW | Tx3-TP01 | 1 | Unknown |
| GCCIEPLCYQYDCDCCRYL | Cp3-D03 | 1 | Unknown |
| ECSSPDESCTYHYNCCQLYCNKEENVCLENSPEV | LtVIB | 1 | Unknown |
| ECRGYNAPCSAGAPCCSWWTCSTQTSRCF | Vc6.10 | 1 | Unknown |
| GCCPIGPCMQSVCSPCCP | Vr3-SP01 | 1 | Unknown |
| GMWGKCKDGLTTCLAPSECCSGNCEQNCKMW | TxMEKL-011, LeD51 | 1 | Unknown |
| GVWSECSDWLAGCSSPSECCSEKCDTFCRLW | G6.8 | 1 | Unknown |
| GWDTPAPCRYCQWNGPQCCVYYCSSCNYEEARE– | |||
| EGHYVSSHLLERQ | Cal6.3a | 1 | Unknown |
| DECCEPQWCDGACDCCS | LtIIIA | 1 | iota |
| KFILHALGQWQCCTMQWCDKACYCCE | Vc3.4 | 1 | Unknown |
| DDCTTYCYGVHCCPPAFKCAASPSCKQT | Cal6.5a | 1 | Unknown |
| KTCQRRWDFCPGSLVGVITCCGGLICFLFFCV | Om6.6 | 1 | Unknown |
| LCPDYTEPCSHAHECCSWNCYNGHCTG | Gla(3)-TxVI | 1 | Unknown |
| MQGKISSEQHPMFDPIEGCCTQSCTTCFPCCLI | Lt3.6 | 1 | Unknown |
| DCCSMSACVPPPACECC | Mi3-E04 | 1 | Unknown |
| DCCPLPACPFGCNPCCGWPALLSGPHQVMNNE | Mr020 | 1 | Unknown |
| DCCGVKLEMCHPCLCDNSCKNYGK | PIVE | 1 | kappa |
| DAMQKSKGSGSCAYISEPCDILPCCPGLKCNEDFVPICL | LtVIA | 1 | Unknown |
| NPKLSKLTKTCDPPGDSCSRWYNHCCSKLCTSR– | |||
| NSGPTCSRP | LiCr95 | 1 | Unknown |
| QCADLGEECYTRFCCPGLRCKDLQVPTCLLA | Ar6.10 | 1 | Unknown |
| QCCDSNSCEYPKCLCCN | Tx3-L02, Vr3-L01, Vt3-L01, S3-L02 | 1 | Unknown |
| CVEDGDFCGPGYEECCSGFCLYVCI | Pu6.2 | 1 | Unknown |
| QKCCGKGMTCPRYFRDNFICGCC | CnIIIG | 1 | Unknown |
| QQCCPPVACNMGCEPCC | TxMMSK-04, Vt3-EP01 | 1 | Unknown |
| RCCGEGASCPVYSRDRLICSCC | CnIIIE | 1 | Unknown |
| RCCISPACNDTCYCCQD | Vr3-Y02, Vt3-Y01, Ts3-Y01 | 1 | Unknown |
| CPNTGELCDVVEQNCCYTYCFIVVCPI | Mr6.2 | 1 | Unknown |
| RCCTGKKGSCSGRACKNLKCCA | SxIIIA | 1 | mu |
| APWTVVTATTNCCGITGPGCLPCRCTQTC | A4.4 | 1 | Unknown |