Table A1.
List of conotoxins with corresponding PDB structure IDs [55] comprising the 4C library. Name or names of sequences are taken from the Conoserver database [40]. Multiple names for the same sequence indicate the same sequence is produced by different species or has different post-translational modifications.
| Name(s) | PDB ID | Sequence |
|---|---|---|
| EpI [sTy15>Y], EpI | 1a0m | GCCSDPRCNMNNPDYC |
| PnIB, PnIB [sTy15Y] | 1akg | GCCSLPPCALSNPDYC |
| CnIA | 1b45 | GRCCHPACGKYYSC |
| AuIB, Ac-AuIB, AuIB [ribbon isoform] | 1mxp | GCCSYPPCFATNPDC |
| ImI [R11E] | 1e74 | GCCSDPRCAWEC |
| ImI [R7L] | 1e75 | GCCSDPLCAWRC |
| ImI [D5N] | 1e76 | GCCSNPRCAWRC |
| TIA | 2lr9 | FNWRCCLIPACRRNHKKFC |
| MrIB, MrIB C-term amidated | 1ieo | VGVCCGYKLCHPC |
| EI | 1k64 | RDPCCYHPTCNMSNPQIC |
| GID, GID*, GID*-NH2, GID*[O16P] | 1mtq | IRDECCSNPACRVNNPHVC |
| SI | 1hje | ICCNPACGPKYSC |
| TXIX | 1wct | ECCEDGWCCXAAP |
| GI | 1xga | ECCNPACGRHYSC |
| Conkunitzin-S1 | 1y62 | RPSLCDLPADSGSGTKAEKRIYYNSARKQ-CLRFDYTGQGGNENNFRRTYDCQRTCL |
| PIA, PIA [R1ADMA] | 1zlc | RDPCCSNPVCTVHNPQIC |
| cMII-6 | 2ajw | GCCSNPVCHLEHSNLCGGAAGG |
| PlXIVA | 2fqc | FPRPRICNLACRAGIGHKYPFCHCR |
| GI (SER12)-benzoylphenylalanine | 2fr9 | ECCNPACGRHYYC |
| GI (ASN4)-benzoylphenylalanine | 2frb | ECCYPACGRHYSC |
| OmIA | 2gcz | GCCSHPACNVNNPHICG |
| BuIA, BuIA[P6O], BuIA[P7O] | 2ns3 | GCCSTPPCAVLYC |
| ImI [P6A] | 2ifi | GCCSDARCAWRC |
| ImI [P6K], ImI [P6K] deamidated | 2ifj | GCCSDKRCAWRC |
| ImI, ImI [C2U,C8U], ImI [C2U,C3U,C8U,C12U], ImI deamidated, A c-ImI, ImI [A9S], ImI [C3U,C12U], ImI [P60], ImI [P6APro], ImI [P6A(S)Pro], ImI [P6guaPro], ImI [P6betPro], ImI [P6fluoPro], ImI [P6fluo(S)Pro], ImI [P6phiPro], ImI [P6phi(S)Pro], ImI [P6benzPro], ImI [P6naphPro], ImI [P6phi(3S)Pro], ImI [P6phi(5R)Pro] | 2bypF | GCCSDPRCAWRC |
| CMrVIA [K6P], CMrVIA [K6P] amidated | 2ih7 | VCCGYPLCHPC |
| CMrVIA, CMrVIA amidated | 2b5p | VCCGYKLCHPC |
| Cyclic MrIA | 2j15 | NGVCCGYKLCHPCAG |
| RgIA [P6V] | 2juq | GCCSDVRCRYRCR |
| RgIA [D5E] | 2jur | GCCSEPRCRYRCR |
| RgIA [Y10W] | 2jus | GCCSDPRCRWRCR |
| RgIA | 2jut | GCCSDPRCRYRCR |
| Pc16a | 2ler | SCSCKRNFLCC |
| Midi | 2lu6 | CNCSRWARDHSRCC |
| TxIB | 2lz5 | GCCSDPPCRNKHPDLC |
| Li1.12, TxID | 2m3i | GCCSHPVCSAMSPIC |
| Ar1248 | 2m62 | GVCCGVSFCYPC |
| Lo1a | 2md6 | EGCCSNPACRTNHPEVCD |
| LvIA | 5xgl | GCCSHPACNVDHPEIC |
| Exendin-4/conotoxin chimera (Ex-4[1-27]/pl14a) | 2naw | HGEGTFTSDLSKQMEEEAVRC-FIECLKGIGHKYPFCHCR |
| Bt1.8 | 2nay | GCCSNPACILNNPNQC |
| TXIA(A10L) | 2uz6 | GCCSRPPCILNNPDLC |
| CnVA | 3zkt | ECCHRQLLCCLRFV |
| Cyclic Vc1.1 | 4ttl | GCCSDPRCNYDHPEICGGAAGG |
| GIC | 1ul2 | GCCSHPACAGNNQHIC |
| PeIA, Bt1.4, PeIA[P6O], PeIA[P13O] | 5jmeF | GCCSHPACSVNHPELC |
| Pn10.1 | 5t6v | STCCGYRMCVPC |
| LsIA, LsIA# | 5t90F | SGCCSNPACRVNNPNIC |
| VilXIVA | 6efe | GGLGRCIYNCMNSGGGLSFIQCKTMCY |