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. 2020 May 20;12(5):1289. doi: 10.3390/cancers12051289

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Protein–protein interaction network of 17 cancer related genes and MUS81, highlighting the most likely biologically relevant links among the selected proteins. Nodes represent proteins and lines represent physical protein interactions between them. Red outline identifies the 18 targets, including MUS81 and 17 cancer-related genes, with variants identified by whole-exome sequencing. Gray lines represent low connectivity (low degree), while blue lines link proteins with the highest degree between target genes via XRRC6, SMAD2 and CDK1, and red lines represent direct interactions between targets.