Table 1.

Studies Characteristics.

Mechanisms	Studies n = 66
	49 Preclinical	17 Clinical
Glycolysis and Oxidative	15 (22.7%)	2(3%)
Arginine, Tryptophan and Glutamine	18 (27.3%)	1 (1.5%)
Lipids	3 (4.5%)	1 (1.5%)
Microbiota	3 (4.5%)	11 (16.6%)
Mixed	10 (15%)	4 (6%)