Table 2.

The effects of obesity on immune checkpoint blockade therapy for cancer trialled in animal studies.

Study Authors	Date of Study	Type of Study	Cancer	Drug Name	Statistical Effect of Obesity
Animal trials
Murphy et al. [80]	August 2018	Tumour trial	Renca (renal adenocarcinoma)	Anti-CTLA-4	Compared to control, increased survival in lean mice (p = 0.007) and ob/ob mice (p = 0.005) but not DIO mice (p = 0.095), no other statistics provided
Wang et al. [54]	November 2018	Tumour trial	B16 (melanoma)	Anti-PD-1	DIO mice have reduced tumour growth by day 16 (p < 0.005), no other statistics provided
Wang et al. [54]	November 2018	Tumour trial	3ll (lung cancer)	Anti-PD-1	DIO mice have reduced tumour growth by day 11 (p < 0.001), no other statistics provided