Table 3.

Ongoing phase 3 trials of rucaparib monotherapy or combination therapy.

Therapy	Trial Name	Intervention	Study Population
Rucaparib alone	ARIEL 4   (NCT02855944)	Rucaparib versus platinum-based chemotherapy for relapsed ovarian cancer	Recurrent advanced stage BRCA-mutated ovarian, fallopian and primary peritoneal cancers with ≥ 2 prior lines of chemotherapy
Rucaparib plus VEGF inhibitor	MAMOC   (NCT04227522)	Rucaparib maintenance after bevacizumab maintenance following carboplatin-based first-line chemotherapy	Newly diagnosed advanced-stage ovarian, fallopian and primary peritoneal cancers, with at least stable disease after carboplatin-based chemotherapy, cytoreductive surgery and upfront + maintenance bevacizumab
Rucaparib plus immunotherapy	ATHENA   (NCT03522246)	Rucaparib and nivolumab maintenance following response to primary platinum-based chemotherapy	Newly diagnosed advanced-stage ovarian, fallopian and primary peritoneal cancers treated with primary platinum-based chemotherapy and cytoreductive surgery