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. 2020 May 13;12(5):1227. doi: 10.3390/cancers12051227

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Enhanced cell migration and invasion in LINC00261^low cells. (a,b) Cell doubling time in PANC-1 cells after CRISPRi-mediated LINC00261 downregulation and in three wild-type and three LINC00261 promoter knockout cell clones (** p < 0.01, one-way (a) and two-way ANOVA (b)). (c,d) Transwell migration (c) and invasion (d) assays in PANC-1 cells after CRISPRi-mediated LINC00261 downregulation (* p < 0.05, ** p < 0.01, one-way ANOVA). (e,f) Transwell migration (e) and invasion (f) assays in PANC-1 cells after CRISPR/Cas9-mediated knockout of LINC00261 promoter. Quantification of migrated and invaded cells (c–f) from five random fields of three wild-type and three knockout clones after eosin Y and methylene blue staining using light microscopy (**** p < 0.0001, two-way ANOVA).