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. 2020 May 16;18(5):261. doi: 10.3390/md18050261

Figure 5.

Figure 5

Inhibitory effects of the PI3K and MAPK pathways on the proliferation and phosphorylation of target proteins in ovarian cancer cells. Effects of inhibitors LY294002 (20 μΜ, AKT), U0126 (20 µM, ERK1/2), SP600125 (20 µM, JNK), and SB203580 (20 µM, p38) with fucosterol (100 µM) on cell proliferation (A) and phosphorylation of CCND1 (B), AKT (C), P70S6K (D), S6 (E), ERK1/2 (F), JNK (G), and P38 (H) in both ES2 and OV90 cells. Values of phosphoprotein intensity were normalized to the intensity of each total protein and are expressed relative to that of the vehicle-treated control cells. Asterisks indicate significant effects compared to the control (* p < 0.05, ** p < 0.01, and *** p < 0.001).