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. 2020 May 13;12(5):1216. doi: 10.3390/cancers12051216

Figure 2.

Figure 2

pS670-GRK2 modulates hypoxia-induced HuR upregulation. (A,B) HeLa stable cell lines were cultured under hypoxia and the pSer670 GRK2, GRK2, and HuR levels were analyzed by immunoblotting, at the indicated times. Values are mean ± SEM from 4–6 independent experiments. Upper panel: ‡ p < 0.05 wt5 vs. parental; # p < 0.05 A1 vs. parental; * p < 0.05 K1 vs. parental; † p < 0.05 shGRK2 vs. parental (Student’s t-test). Lower panel: * p < 0.05 A1 and K1 vs. parental; † p < 0.05 A1 and K1 vs. WT5 (Student’s t-test). Detailed information about the Western blots can be found in Figure S4.