Table 2.
Infectious pathogen-specificity of monoclonal Igs in MGUS/SMM and MM according to the presence or absence of non-clonal GlcSph-reactive Igs.
| Patients * | Without GlcSph-Reactive Igs |
With Non-Clonal GlcSph-Reactive Igs * | p Value |
|---|---|---|---|
| MGUS/SMM | n = 75 | n = 44 | – |
| EBV (EBNA-1) | 37 (49.3%) 1 | 16 (36.4%) | NS |
| Other pathogen of the MIAA | 17 (22.7%) 2 | 18 (40.9%) 4 | p = 0.0398 6 |
| Unknown | 21 (28.0%) 3 | 10 (22.7%) 5 | NS |
| MM | n = 55 | n = 22 | – |
| EBV (EBNA-1) | 15 (27.3%) | 7 (31.8%) | NS |
| Other pathogen of the MIAA | 4 (7.3%) | 3 (13.6%) | NS |
| Unknown | 36 (65.4%) | 12 (54.5%) | NS |
* This analysis was performed without the 37 patients (24 MGUS, 13 MM) who presented with a GlcSph-reactive monoclonal Ig. Significant differences observed using the Fisher exact test: 1 p = 0.0121, 2 p = 0.0282 and 3 p < 0.0001, MGUS/SMM vs. MM without GlcSph-reactive Igs; 4 p = 0.0466 and 5 p = 0.0108, MGUS/SMM vs. MM with non-clonal GlcSph-reactive Igs; 6 MGUS/SMM patients with vs. without GlcSph-reactive Igs. MIAA: multiplex infectious antigen microarray. NS: not significant.