Figure 5.

In vivo therapeutic efficacy of drug-loaded liposomes in an orthotopic pancreatic tumor model. Briefly, 1 × 10⁶ AsPC-1 cells were orthotopically injected into the head of the pancreases of 6–8 weeks old female mice. After 10 days of cells implantation, mice were imaged by using IVIS and randomized into five groups (n = 5 in each group). Then, mice were treated with indicated groups 2×/week for 3 weeks. (A) The graphical representation of in vivo experimental plan. After the end of the treatment, mice were sacrificed, and endpoint tumor volume (B) and tumor weight (C) were measured. *** denotes p < 0.001 compared to control; ** denotes p < 0.01 compared to G-L group; and * denotes p < 0.05 compared to G-L group. (Abbreviations: G-L represents liposomal gemcitabine; GP-L represents liposome loaded with both gemcitabine and paclitaxel; GE-L represents liposome loaded with both gemcitabine and erlotinib, GX-L represents liposome loaded with both gemcitabine and XL-184).