Table 2.
Total lipid weight, initial drug amount added, drug-loading efficiency (DLE), and encapsulation efficiency (EE) of single or dual drug-loaded liposomal formulations.
| Liposome | Total Lipid (mg/mL) | Initial Drug Added (mg/mL) | DLE (%) | EE (%) | |||
|---|---|---|---|---|---|---|---|
| G | P | E | X | ||||
| L | 5.487 | – | – | – | – | – | – |
| P-L | 5.487 | – | 0.1 | 1.5 ± 0.02 | 81.1 ± 1.5 | ||
| E-L | 5.487 | – | – | 0.2 | – | 2.6 ± 0.12 | 70.7 ± 3.9 |
| X-L | 5.487 | – | – | – | 0.150 | 1.82± 0.07 | 66.5 ± 2.9 |
| G-L | 5.487 | 1 | – | – | 3.3 ± 0.39 | 18.1 ± 2.1 | |
| GP-L | 5.487 | 1 | 0.1 | 4.5 ± 0.15(G); 1.45 ± 0.07(P) |
24.6 ± 0.8(G); 79 ± 3.8(P) |
||
| GE-L | 5.487 | 1 | – | 0.2 | 3.1 ± 0.32(G); 2.8 ± 0.08(E) |
16.9 ± 1.7(G); 77.3 ± 2.3(E) |
|
| GX-L | 5.487 | 1 | – | – | 0.150 | 4.8 ± 0.06(G); 2 ± 0.06(X) |
26.6 ± 0.37 (G); 75.4 ± 2.2(X) |
Abbreviations: G-gemcitabine; P-paclitaxel; E-erlotinib; X-XL-184; DLE, drug-loading efficiency; EE, encapsulation efficiency.