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Survival analysis of (A) BRAF mutant human cancers by the presence or absence of truncating APC mutation. (B) Apc, Braf, and Apc/Braf mutant murine models. p-values are univariate and derived from the log-rank test. (C–E) Assessment of the number and size of lesions in Apc, Braf, and Apc/Braf mutant mouse models. (C) Total lesions in the small intestine. (D) Total number of lesions in the colon and caecum. E: Mean size of lesions in the colon and caecum.
