Table 2.

Comparison of the mutational frequency of WNT signaling regulators in BRAF mutant cancers versus BRAF wild type cancers.

Gene	Samples Mutated (BRAF Mutant)	Samples Mutated (BRAF Wild Type)	Adjusted p Value	Odds-Ratio (Mutant/Wild Type)
APC	57	420	7.18 × 10−39	0.09
RNF43	82	29	2.90 × 10−26	11.52
ZNRF3	38	7	3.67 × 10−14	16.84
ITPR3	51	25	3.27 × 10−12	6.65
KMT2D	66	49	2.53 × 10−11	4.64
TRRAP	60	40	2.53 × 10−11	5.04
CREBBP	51	37	9.61 × 10−09	4.38
DVL2	24	6	6.25 × 10−08	11.45
FZD8	20	3	8.60 × 10−08	18.77
CHD8	45	32	8.92 × 10−08	4.34
TERT	19	3	2.34 × 10−07	17.74
LRP5	29	13	2.72 × 10−07	6.49
WNT16	25	9	3.74 × 10−07	7.96
SCRIB	28	16	1.10 × 10−05	5.03
ROR2	29	18	1.10 × 10−05	4.64
BCL9L	39	33	1.76 × 10−05	3.51
AKT1	16	4	1.95 × 10−05	11.00
SOX3	17	5	1.99 × 10−05	9.38
WNT4	13	2	3.38 × 10−05	17.66