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. 2020 May 18;9(5):386. doi: 10.3390/pathogens9050386

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Fecal gut microbiota composition prior and post C. coli infection of TLR4-deficient IL10^-/- mice with a human gut microbiota. IL10^-/- mice (open circles; n = 18) and TLR4-deficient IL10^-/- mice (TLR4^-/- IL10^-/-; closed circles; n = 19) harboring a human gut microbiota were perorally infected with a C. coli patient isolate on day (d) 0 and d1 by gavage. Immediately before (i.e., d0) and on d21 post-infection, the fecal microbiota composition was determined by quantitative 16S rRNA based Real-Time PCR, and expressed as copies per ng DNA: (A) Total eubacterial load; (B) enterobacteria; (C) enterococci; (D) lactobacilli; (E) bifidobacteria; (F) Bacteroides/Prevotella species; (G) Mouse Intestinal Bacteroides; (H) Clostridium coccoides group; (I) Clostridium leptum group. Medians (black bars) and levels of significance (p-values) assessed by the Kruskal–Wallis test and Dunn’s post-correction are indicated. Shown data were pooled from three independent experiments.