Figure 1.

Effects of KIT inhibitors on proliferation and signaling. (A) Cells were treated with DMSO or 1 µM of inhibitors and proliferation was analyzed after 3 days (data are represented as mean +/− SD). All inhibitors induced a significant inhibition a proliferation in the three cell lines (p < 0.001; unpaired t-test). (B) Cells were treated for 24 h with DMSO or 1 µM inhibitors and the levels of phosphorylated proteins or total proteins were analyzed by Western blotting.