Skip to main content
. 2020 Apr 25;12(5):1062. doi: 10.3390/cancers12051062

Figure 3.

Figure 3

Effects of FGF2 on proliferation and signaling. (A) Cells were treated with DMSO or 1 µM of inhibitors in the absence or in the presence of 20 ng/mL FGF2 and proliferation was analyzed after 3 days (data are represented as mean +/− SD). The effect of all KIT inhibitors was significantly reduced in all three cell lines in the presence of FGF2 (M230, p < 0.002; HBL, p < 0.01; LND1, p < 0.02; unpaired t-test). (B) Cells were treated for 24 h with DMSO or 1 µM nilotinib in the absence or in the presence of 20 ng/mL FGF2 and the levels of cleaved proteins (cPARP and cCaspase 7) or total protein were analyzed by Western blotting.