Table 3.
Association between background clinical variables and freedom of liver recurrence (FLR), disease-free survival (DFS) and overall survival (OS) in hepatocellular carcinoma patients who underwent surgical treatments. p-Value from Wald test in a univariable Cox regression using log-transformed covariates.
| Clinical Variables/ Outcome |
FLR | DFS | OS | |||
|---|---|---|---|---|---|---|
| HR [95% CI] (n) | p-Value | HR [95% CI] (n) | p-Value | HR [95% CI] (n) | p-Value | |
| All patients | ||||||
| Milan criteria | 0.58 [0.33,1.03] (173) | 0.065 | 0.64 [0.43, 0.97] (173) | 0.034 | 0.53 [0.34, 0.81] (173) | 0.0037 |
| Edmondson–Steiner grade | 4.45 [0.97,20.40] (160) | 0.054 | 1.75 [0.82, 3.71] (160) | 0.15 | 1.41 [0.63, 3.16] (160) | 0.40 |
| Tumor size | 1.03 [0.96, 1.11] (171) | 0.38 | 1.06 [1.00, 1.12] (171) | 0.050 | 1.06 [1.00, 1.12] (170) | 0.042 |
| HBV | 2.08 [1.20, 3.63] (179) | 0.0097 | 1.29 [0.87, 1.91] (179) | 0.21 | 1.06 [0.70, 1.61] (178) | 0.77 |
| HCV | 0.73 [0.41, 1.30] (179) | 0.28 | 0.83 [0.55, 1.24] (179) | 0.36 | 0.90 [0.59, 1.38] (178) | 0.63 |
| HDV | 1.48 [0.63, 3.48] (179) | 0.37 | 1.03 [0.54, 1.98] (179) | 0.92 | 0.85 [0.44, 1.65] (178) | 0.64 |
| LT | ||||||
| Milan criteria | 0.38 [0.09, 1.51] (54) | 0.17 | 0.48 [0.20, 1.16] (54) | 0.10 | 0.53 [0.21,1.31] (54) | 0.17 |
| Edmondson–Steiner grade | NA [NA, NA] (44) | N/A | 1.48 [0.27, 8.11] (44) | 0.65 | 1.58 [0.29, 8.66] (44) | 0.60 |
| Tumor size | 1.54 [0.97, 2.45] (53) | 0.067 | 1.27 [0.96, 1.66] (53) | 0.067 | 1.26 [0.95, 1.67] (52) | 0.11 |
| HBV | 1.69 [0.34, 8.39] (60) | 0.52 | 1.33 [0.52, 3.41] (60) | 0.55 | 1.45 [0.53, 3.98] (59) | 0.47 |
| HCV | 0.78 [0.16, 3.89] (60) | 0.77 | 0.56 [0.19, 1.65] (60) | 0.29 | 0.45 [0.13, 1.52] (59) | 0.20 |
| HDV | 0.73 [0.17, 3.05] (60) | 0.66 | 0.69 [0.29, 1.65] (60) | 0.41 | 0.71 [0.29, 1.71] (59) | 0.45 |
| LR | ||||||
| CTP Score | 2.72 [1.05, 7.05] (120) | 0.039 | 2.71 [1.41, 5.23] (120) | 0.0029 | 3.26 [1.66, 6.42] (120) | 0.0006 |
| Milan criteria | 0.64 [0.34, 1.18] (119) | 0.15 | 0.70 [0.44, 1.09] (119) | 0.11 | 0.53 [0.32, 0.86] (119) | 0.011 |
| Edmondson–Steiner grade | 3.79 [0.83, 17.31] (116) | 0.086 | 1.82 [0.76, 4.35] (116) | 0.18 | 1.39 [0.55, 3.52] (116) | 0.49 |
| Tumor size | 1.02 [0.95, 1.10] (118) | 0.067 | 1.05 [0.99, 1.11] (118) | 0.10 | 1.05 [0.99, 1.12] (118) | 0.083 |
| HBV | 2.14 [1.19, 3.86] (119) | 0.011 | 1.28 [0.83, 1.98] (119) | 0.27 | 0.00 [0.62, 1.57] (119) | 0.97 |
| HCV | 0.72 [0.39, 1.33] (119) | 0.30 | 0.89 [0.57, 1.39] (119) | 0.61 | 1.03 [0.64, 1.64] (119) | 0.91 |
| HDV | 2.13 [0.84, 5.42] (119) | 0.11 | 1.66 [0.72, 3.84] (119) | 0.24 | 1.07 [0.43, 2.65] (119) | 0.89 |
CTP, Child–Turcotte–Pugh; HBV, hepatitis B virus; HCV, hepatitis C virus; HDV, hepatitis D virus; LR liver resection; LT, liver transplantation.