Table 7.
Analysis of plasma VEGF and VEGF-C combined with Milan criteria and AFP in hepatocellular carcinoma patients who underwent liver transplantation. Analysis was performed in proportional hazards regression model, with log-transformed VEGF or VEGF-C and AFP measurements and either stratifying on Milan criteria as a stratum variable or including Milan criteria in regression. Data are presented as C-statistic with 95% confidence intervals.
| Biomarkers/ Outcome |
Plasma VEGF | Plasma VEGF-C | ||||
|---|---|---|---|---|---|---|
| DFS | C-statistic | χ2 | p-value | C-statistic | χ2 | p-value |
| Milan as stratum | 0.690 (0.578, 0.802) | 8.22 | 0.0042 | 0.620 (0.453, 0.788) | 6.18 | 0.013 |
| Milan in regression | 0.729 (0.624, 0.835) | 8.44 | 0.0037 | 0.692 (0.555, 0.830) | 5.95 | 0.015 |
| OS | C-statistic | χ2 | p-value | C-statistic | χ2 | p-value |
| Milan as stratum | 0.674 (0.562, 0.785) | 6.12 | 0.013 | 0.629 (0.461, 0.797) | 5.86 | 0.016 |
| Milan in regression | 0.700 (0.585, 0.815) | 5.98 | 0.015 | 0.686 (0.543, 0.830) | 6.54 | 0.011 |
AFP, alpha-fetoprotein; VEGF, vascular endothelial growth factor.