Table 2.
Characteristics of the studies on disease-free survival outcomes of breast cancer patients according to cathepsin D status.
| Author | No. of patients High CTSD/low CTSD (Total patients) |
Median follow-up (months) | Survival analysis test | Detection method | Staining location | Cut-off value (low/high level) |
|---|---|---|---|---|---|---|
| Granata et al.43 | 67/68 (135) | 87 | KM plot | ELSA | cytosol | High (>40 pmol/mg) |
| Pujol et al.28 | 64/59 (123) | 59 | KM plot | ELSA | cytosol | High (>20 pmol/mg) |
| Tetu et al.44 | 262/376 (638) | 58 | KM plot | IHC | cytosol | High (stained 10%) |
| Ferno et al.45 | 184/70 (153) | 37 | KM plot | ELSA | cytosol | High (>45 pmol/mg) |
| Donoghue et al.31 | 75/28 (103) | 60 | KM plot | IHC | stromal cell | High (stained 25%) |
| Foekens et al.33 | 1405/1405 (2810) | 88 | KM plot | ELSA | cytosol | High (>45.2 pmol/mg) |
| Jahkola et al.46 | 54/65 (119) | 94 | Univariate | IHC | stromal cell | High (stained 10%) |
| Billgren et al.47 | 707/214 (921) | 59 | Univariate | ELSA | cytosol | High (>10 pmol/mg) |
| Rodriguez et al.36 | 307/696 (1003) | 54 | KM plot | ELSA | cytosol | High (>59 pmol/mg) |
| Jacobson et al.39 | 252/18 (270) | 126 | Univariate | IHC | cytosol | High (> third quartile) |
| Chen et al.40 | 155/44 (199) | 60 | Univariate | IHC | cytosol | High (stained 10%) |
| Markićević et al.48 | 39/19 (58) | 18 | KM plot | ELSA | cytosol | High (>39 pmol/mg) |
| Tazhibi et al.49 | 637/38 (675) | 59 | KM plot | IHC | cytosol | High (stained 20%) |
| Huang et al.41 | 140/45 (185) | 66 | Univariate | IHC | cytosol | High (stained 20%) |
| Sun et al.50 | 91/64 (155) | NA | KM plot | IHC | cytosol | High (stained 26%) |
CTSD, cathepsin D; ELSA, immunoradiometric assay; IHC, immunohistochemistry; KM plot, Kaplan–Meier plot.