Figure.

Evidence Description for COVID-19 Studies*.

COVID-19 = coronavirus disease 2019; RCT = randomized controlled trial.

* Evidence search was conducted by the University of Connecticut Health Outcomes, Policy, and Evidence Synthesis Group. Current search for evidence, completed on 17 April 2020, aimed to identify all studies about the use of chloroquine or hydroxychloroquine alone or in combination for prophylaxis or treatment of patients with COVID-19. (See Supplement, available at Annals.org.)

† The use and extent of parallel treatment interventions was difficult to determine. For example, in some studies, it was documented that patients received parallel interventions, whereas in other studies there was insufficient information to determine if patients did or did not receive parallel interventions.

‡ In 2 cohort studies (11, 12), the administration of azithromycin was not randomized, precluding judgment of efficacy