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. 2020 May 22:M20-2306. doi: 10.7326/M20-2306

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This article is made available via the PMC Open Access Subset for unrestricted re-use for research, analyses, and text and data mining through PubMed Central. Acknowledgement of the original source shall include a notice similar to the following: "© 2020 American College of Physicians. Some rights reserved. This work permits non-commercial use, distribution, and reproduction in any medium, provided the original author and source are credited." These permissions are granted for the duration of the COVID-19 pandemic or until permissions are revoked in writing. Upon expiration of these permissions, PMC is granted a perpetual license to make this article available via PMC and Europe PMC, consistent with existing copyright protections.

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Figure 2. — Mortality with NIV compared with no MV.

One RCT (32) suggests a reduction in mortality, but there were only 3 events in 60 patients in total, causing imprecision. The nonrandomized study by Xu and colleagues (12) showed a reduction in mortality. IV = inverse variance; MERS = Middle East respiratory syndrome; MV = mechanical ventilation; NIV = noninvasive ventilation; NRS = nonrandomized study; RCT = randomized controlled trial; SARS = severe acute respiratory syndrome.