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Cellular activities of IGFBPs in IGF signaling. IGFBPs modulate the bioavailability of IGFs to their receptors. Proteolytic cleavage by specific proteases and interactions with extracellular matrix components provide a reservoir of bioactive IGFs that stimulate intracellular signaling cascades for the transcription of respective genes. Red arrow indicates a weak affinity, and a green arrow indicates a strong affinity of IGFBP to its binding partner.
