Table 2.

Univariate and multivariate analysis for overall survival.

	Univariate analysis			Multivariate analysis
Variables	Hazard ratio	95% CI	P value	Hazard ratio	95% CI	P value
DACH1 (high)	3	1.782–5.052	<0.001	2.177	1.263–3.755	0.005
Male gender	0.7	0.411–1.193	0.19	NA
Age >70	1.235	0.750–2.034	0.407	NA
T stage, T4	6.55	1.595–6.925	0.009	1.712	1.014–2.890	0.044
N stage, N2	4.05	2.140–7.655	<0.001	1.326	0.934–1.883	0.115
M1 stage	9.23	5.502–5.487	<0.001	2.803	1.266–6.204	0.011
Grade, poor	1.38	0.834–2.306	0.21	0.931	0.3–2.891	0.901
Lymph node examined	0.613	0.326–1.151	0.128	NA
Mucinous Adenocarcinoma	0.567	0.139–2.321	0.43	NA
Perineural invasion	1.557	0.845–2.87	0.156	NA
Vascular invasion	2.038	1.252–3.319	0.004	0.91	0.721–2.066	0.459
Adjuvant therapy	2.599	1.892–3.571	<0.001	1.78	1.205–2.634	0.004
MSI	1	0.599–1.667	0.999	NA
CEA >10 ng/mL	1.841	1.151–2.943	0.01	1.91	1.159–3.151	0.011

MMR indicates mismatch repair; MS, microsatellite; MSS, microsatellite stability; MSI, microsatellite instability; LN, lymph nodes.