Table 3.

Univariate and Multivariate analyses of prognostic factors for disease-free survival.

	Univariate Analysis			Multivariate Analysis
Variables	Hazard ratio	95% CI	P value	Hazard ratio	95% CI	P value
DACH1 (high)	2.251	1.606–4.053	<0.001	1.76	1.079–2.874	0.023
Male gender	0.674	0.415–1.095	0.111	NA
Age >70	1.185	0.752–1.868	0.464	NA
T stage, T4	5.294	1.661–16.871	0.005	1.558	0.977–2.487	0.063
N stage, N2	3.735	2.098–6.649	<0.001	1.207	0.881–1.654	0.24
M1 stage	9.892	6.064–16.136	<0.001	7.249	3.968–13.241	<0.001
Grade, poor	1.233	0.779–1.953	0.371	NA
Lymph node examined	0.635	0.349–1.155	0.137	NA
Mucinous Adenocarcinoma	0.447	0.110–1.823	0.262	NA
Perineural invasion	1.514	0.859–2.669	0.152	NA
Vascular invasion	1.832	1.175–2.857	0.008	0.751	0.449–1.255	0.274
Adjuvant therapy	0.689	0.335–1.419	0.313	NA
MSI	0.97	0.611–1.539	0.896	NA
CEA >10 ng/mL	1.588	1.040–2.425	0.032	1.421	0.910–2.218	0.122

MMR indicates mismatch repair; MS, microsatellite; MSS, microsatellite stability; MSI, microsatellite instability; LN, lymph nodes.