Table 2.
Adjusted associations between categories of leukocyte and its subtypes and prevalence of benign breast diseasea.
| Quintiles of leukocyte and its subtypes concentration (×109/L) | P for trendb, g | |||||
|---|---|---|---|---|---|---|
| Level 1 | Level 2 | Level 3 | Level 4 | Level 5 | ||
| Serum leukocyte concentration (×109/L, range) | 3.92–4.71 | 4.71–5.40 | 5.40–6.10 | 6.10–7.40 | ≥7.40 | |
| No. of subjects | 1170 | 1241 | 1048 | 1180 | 1203 | — |
| No. of BBD | 258 | 272 | 207 | 242 | 242 | — |
| Model 1c | 1.00 (reference) d | 0.99 (0.82, 1.20) | 0.87 (0.71, 1.07) | 0.91 (0.75, 1.11) | 0.89 (0.73, 1.08) | 0.18 |
| Model 2e | 1.00 (reference) | 1.01 (0.83, 1.23) | 0.90 (0.73, 1.10) | 0.95 (0.78, 1.16) | 0.93 (0.76, 1.14) | 0.40 |
| Model 3f | 1.00 (reference) | 1.01 (0.83, 1.22) | 0.90 (0.73, 1.11) | 0.94 (0.77, 1.16) | 0.92 (0.75, 1.14) | 0.37 |
|
| ||||||
| Serum neutrophil concentration (×109/L, range) | 2.00–2.58 | 2.58–3.05 | 3.05–3.60 | 3.60–4.63 | ≥4.63 | |
| No. of subjects | 1193 | 1161 | 1101 | 1215 | 1172 | — |
| No. of BBD | 266 | 232 | 218 | 245 | 260 | — |
| Model 1c | 1.00 (reference) | 0.87 (0.71, 1.06) | 0.86 (0.70, 1.05) | 0.88 (0.72, 1.07) | 0.99 (0.81, 1.21) | 0.82 |
| Model 2e | 1.00 (reference) | 0.90 (0.74, 1.10) | 0.89 (0.72, 1.08) | 0.92 (0.75, 1.12) | 1.04 (0.85, 1.26) | 0.53 |
| Model 3f | 1.00 (reference) | 0.89 (0.73, 1.09) | 0.88 (0.72, 1.08) | 0.91 (0.74, 1.11) | 1.01 (0.82, 1.24) | 0.71 |
|
| ||||||
| Serum monocyte concentration (×109/L, range) | 0.20–0.27 | 0.27–0.32 | 0.32–0.38 | 0.38–0.48 | ≥0.48 | |
| No. of subjects | 2390 | 995 | 649 | 912 | 896 | — |
| No. of BBD | 532 | 203 | 129 | 181 | 176 | — |
| Model 1c | 1.00 (reference) | 0.90 (0.75, 1.07) | 0.87 (0.70, 1.07) | 0.87 (0.71, 1.04) | 0.85 (0.70, 1.03) | 0.06 |
| Model 2d | 1.00 (reference) | 0.87 (0.72, 1.04) | 0.85 (0.68, 1.05) | 0.85 (0.71, 1.03) | 0.86 (0.71, 1.04) | 0.06 |
| Model 3e | 1.00 (reference) | 0.84 (0.70, 1.01) | 0.84 (0.67, 1.04) | 0.84 (0.69, 1.02) | 0.84 (0.69, 1.02) | 0.05 |
|
| ||||||
| Serum lymphocyte concentration (×109/L, range) | 1.30–1.60 | 1.60–1.81 | 1.81–2.10 | 2.10–2.60 | ≥2.60 | |
| No. of subjects | 1185 | 1206 | 1114 | 1151 | 1186 | — |
| No. of BBD | 275 | 280 | 225 | 229 | 212 | — |
| Model 1c | 1.00 (reference) | 1.00 (0.83, 1.21) | 0.84 (0.69, 1.02) | 0.82 (0.67, 1.00) | 0.72 (0.59, 0.88) | <0.001 |
| Model 2e | 1.00 (reference) | 1.01 (0.83, 1.22) | 0.85 (0.70, 1.04) | 0.83 (0.68, 1.01) | 0.75 (0.61, 0.92) | 0.001 |
| Model 3f | 1.00 (reference) | 0.99 (0.82, 1.2) | 0.85 (0.69, 1.04) | 0.84 (0.68, 1.02) | 0.75 (0.61, 0.92) | 0.002 |
|
| ||||||
| Serum neutrophil-to-lymphocyte ratio (range) | 1.05–1.38 | 1.38–1.66 | 1.66–2.01 | 2.01–2.68 | ≥2.68 | |
| No. of subjects | 1173 | 1164 | 1168 | 1169 | 1169 | — |
| No. of BBD | 241 | 228 | 228 | 264 | 260 | — |
| Model 1c | 1.00 (reference) | 0.94 (0.77, 1.15) | 0.94 (0.77, 1.15) | 1.13 (0.93, 1.38) | 1.11 (0.91, 1.35) | 0.09 |
| Model 2e | 1.00 (reference) | 0.95 (0.77, 1.16) | 0.96 (0.78, 1.17) | 1.15 (0.94, 1.40) | 1.12 (0.92, 1.36) | 0.08 |
| Model 3f | 1.00 (reference) | 0.93 (0.76, 1.14) | 0.94 (0.77, 1.15) | 1.11 (0.91, 1.36) | 1.08 (0.89, 1.32) | 0.15 |
aBBD, benign breast disease. bMultiple logistic regression analysis. cModel 1. Crude.dadjusted odds ratios (95% confidence interval) (all such values). eModel 2, Age- and BMI-adjusted. fModel 3, adjusted for age, body mass index, smoking status, drinking status, fasting blood glucose, systolic blood pressure, total cholesterol, triglycerides, high-density lipoprotein, low-density lipoprotein, surgery history, menopausal status, and family history of cardiovascular disease. gBoldface indicates statistical significance (P < 0.05) (or appropriate value).