Table 3.
Planning target volume (PTV) – specifications for total dose (PTVWB-A = Planning target volume of the whole brain in arm A, PTVWB-B = Planning target volume of the whole brain in arm B, PTVmet = Planning target volume of metastases, PTVres = Planning target volume of resection cavity)
| Parameter | Per Protocol | Minor Deviation | Major Deviation |
|---|---|---|---|
| PTVWB-A or -B |
D98% ≥ 25Gy Dmean ≤ 35 Gy |
24Gy ≤ D98% < 25Gy 35Gy < Dmean ≤ 37 Gy |
D98% < 24Gy Dmean > 37 Gy |
| PTVmet 51Gy (brain metastases) |
D98% ≥ 48.4Gy D2% ≤ 63.7Gy |
47.4Gy ≤ D98% < 48.4Gy 63.7Gy < D2% ≤ 66.3Gy |
D98% < 47.4Gy D2% > 66.3Gy |
|
PTVmet 42Gy (brain stem metastases) PTVres 42Gy |
D98% ≥ 39.9Gy D2% ≤ 52.5 Gy |
39.06 Gy ≤ D98% < 39.9Gy 52.5 Gy < D2% ≤ 54.6 Gy |
D98% < 39.06 D2% > 54.6 Gy |
*PTVWB-A