Table 2.
Univariate and Multivariate Analyses of Prognostic Factors for OS and CSS in patients with non-metastatic RCC (n = 646)
| OS | Multivariate | CSS | Multivariate | |||||
|---|---|---|---|---|---|---|---|---|
| Univariate | Univariate | |||||||
| HR (95% CI) | P-value | HR (95% CI) | P-value | HR (95 CI) | P-value | HR (95% CI) | P-value | |
| Age (≥ 55 vs < 55) | 2.9 (1.79–4.72) | < 0.001 | 1.77 (1.07–2.92) | 0.025 | 2.39 (1.44–3.98) | 0.001 | ||
| Gender (male vs female) | 1.19 (0.76–1.86) | 0.437 | 1.28 (0.78–2.09) | 0.332 | ||||
| Surgical approach (laparoscopic vs open) | 0.29 (0.15–0.56) | < 0.001 | 0.41 (0.21–0.81) | 0.009 | 0.24 (0.11–0.52) | < 0.001 | 0.36 (0.16–0.79) | 0.011 |
| Type of surgery (partial vs radical) | 0.17 (0.08–0.37) | < 0.001 | 0.37 (0.17–0.83) | 0.016 | 0.11 (0.04–0.31) | < 0.001 | 0.29 (0.1–0.82) | 0.019 |
| Histology (non-clear cell vs clear cell) | 0.96 (0.53–1.74) | 0.896 | 1.08 (0.58–2.01) | 0.807 | ||||
| T stage (3–4 vs 1–2) | 8.9 (5.78–13.7) | < 0.001 | 3.99 (2.5–6.37) | < 0.001 | 12.4 (7.77–19.8) | < 0.001 | 5.25 (3.16–8.7) | < 0.001 |
| Tumor grade (G3–4 vs G1–2) | 4.4 (2.69–7.21) | < 0.001 | 1.83 (1.06–3.14) | 0.03 | 5.83 (3.25–10.5) | < 0.001 | 2.15 (1.14–4.08) | 0.019 |
| Tumor necrosis (yes vs no) | 5.29 (3.39–8.26) | < 0.001 | 2.38 (1.49–3.79) | < 0.001 | 6.2 (3.85–9.99) | < 0.001 | 2.65 (1.62–4.36) | < 0.001 |
| Sarcomatoid feature (yes vs no) | 10.66 (4.3–26.4) | < 0.001 | 2.92 (1.14–7.45) | 0.025 | 12.6 (5.06–31.5) | < 0.001 | 3.72 (1.44–9.6) | 0.007 |
| SII (> 529 vs < 529) | 4.23 (2.76–6.49) | < 0.001 | 2.26 (1.44–3.54) | < 0.001 | 4.38 (2.74–7.01) | < 0.001 | 2.17 (1.33–3.55) | 0.002 |