Table 2.
Univariate and multivariate analysis of parameters affecting OS in non-malignancy associated HLH
| Univariate analysis | Multivariate analysis | |||||
|---|---|---|---|---|---|---|
| Treatment response included | Treatment response excluded | |||||
| 5-year OS | P | HR(95%CI) | P | HR(95%CI) | P | |
| Age < 1 years old | 80.0% VS (69.0%) | 0.425 | ||||
| EBV-associated | 79.0% VS (67.0%) | 0.262 | ||||
| Hemoglobin < 60 g/L | 25.0% VS (77.0%) | < 0.001 | 3.22 (2.01–19.28) | 0.002 | ||
| Platelet < 30 × 10^9/L | 36.0% VS (79.0%) | < 0.001 | 2.15 (0.88–5.24) | 0.093 | ||
| ALT > 200 U/L | 73.0% VS (71.0%) | 0.935 | ||||
| TG > 2.5 mg/dl | 76.0% VS (62.0%) | 0.173 | ||||
| Fibrinogen < 1.5 | 66.0% VS (80.0%) | 0.170 | ||||
| Ferritin > 10,000 | 75.0% VS (72.0%) | 0.744 | ||||
| Albumin < 25 g/L | 33.0% VS (82.0%) | < 0.001 | 7.71 (3.10–19.19) | < 0.001 | ||
| Dynamic treatment response | 0.010 | 0.010 | ||||
| Early stable responder | 100% | 0.00 | ||||
| Late stable responder | 100% | 0.00 | ||||
| Unstable responder | 36% | 0.21 (0.08–0.52) | ||||
| Non-responder | 0% | 1.0 | ||||
Abbreviations: OS overall survival, HLH hemophagocytic lymphohistiocytosis, HR hazard ratio, EBV Epstein-Barr virus, ALT alanine transferase, TG triglyceride