Fig. 2.

Exposure to SiNPs induces severe lung injury and inflammation in mice, depending on PARP activation. a Representative lung histopathology on the 7th day in mice after treated with normal saline or SiNPs (10 mg/kg) in the absence or presence of PJ34 (10 mg/kg/d). Black arrows indicate lung tissue edema. Scale bar = 500 μm. b-g Total protein concentrations (b), LDH release (c), total cells numbers (d), macrophages numbers (e), neutrophils numbers (f), and lymphocytes numbers (g) in the BALFs of mice determined on the 7th day after treated with normal saline or SiNPs (10 mg/kg) in the absence or presence of PJ34 (10 mg/kg/d). h-j The concentrations of IL-1β (h), IL-6 (i), and TNF-α (j) in the BALFs of mice under the same conditions as shown for b-g, as markers of local inflammation were measured by ELISA. *P < 0.05, **P < 0.01, ***P < 0.001 compared with the control group. ^#P < 0.05, ^##P < 0.01 compared with SiNPs-treated group