Fig. 9.

TRPM2 deficiency eliminates SiNPs-induced pulmonary inflammation in C57BL/6 mice. a Lung histopathology on the 7th day after treatment with saline or SiNPs (100 μg/mL). Scale bar = 500 μm. b-c Total protein concentrations (b), and LDH (c) in the BALF of Trpm2^−/− mice on the 7th day after exposure to saline or SiNPs (100 μg/mL). d-f Mean concentrations of IL-1β (d), IL-6 (e), and TNF-α (f) in the BALFs measured by ELISA. The data from the WT mice were displayed on the left side of the dotted line, and the Trpm2^−/− data on the right side. * P < 0.05 compared with the control group