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(A) PPI network of upregulated genes, including 386 nodes and 1,105 edges with a PPI enrichment P<1.0x10-16. (B) PPI network of 15 hub genes. (C) PI network of downregulated genes, including 297 nodes and 3,910 edges with a PPI enrichment P<1.0x10-16. PPI, protein-protein interaction.
