Table I.
GO analysis of differentially expressed genes.
| A, Upregulated genes | ||||
|---|---|---|---|---|
| Category | Term | Count | P-value | FDR |
| GOTERM_CC_DIRECT | GO:0005576-extracellular region | 119 | 3.20x10-20 | 4.34x10-17 |
| GOTERM_CC_DIRECT | GO:0070062-extracellular exosome | 166 | 1.25x10-18 | 1.69x10-15 |
| GOTERM_CC_DIRECT | GO:0005615-extracellular space | 99 | 2.59x10-16 | 3.00x10-13 |
| GOTERM_CC_DIRECT | GO:0072562-blood microparticle | 29 | 1.31x10-14 | 1.78x10-11 |
| GOTERM_BP_DIRECT | GO:0055114-oxidation-reduction process | 58 | 4.38x10-14 | 7.78x10-11 |
| GOTERM_MF_DIRECT | GO:0016705-oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | 18 | 5.79x10-13 | 9.05x10-10 |
| GOTERM_BP_DIRECT | GO:0019373-epoxygenase P450 pathway | 12 | 6.99x10-13 | 1.24x10-9 |
| GOTERM_MF_DIRECT | GO:0020037-heme binding | 25 | 3.51x10-12 | 5.48x10-9 |
| GOTERM_MF_DIRECT | GO:0019825-oxygen binding | 16 | 4.49x10-12 | 7.01x10-9 |
| GOTERM_CC_DIRECT | GO:0031090-organelle membrane | 20 | 1.06x10-11 | 1.44x10-8 |
| B, Downregulated genes | ||||
| Category | Term | Count | P-value | FDR |
| GOTERM_BP_DIRECT | GO:0051301-cell division | 38 | 7.08x10-20 | 1.18x10-16 |
| GOTERM_BP_DIRECT | GO:0007067-mitotic nuclear division | 29 | 6.27x10-16 | 1.11x10-12 |
| GOTERM_CC_DIRECT | GO:0000777-condensed chromosome kinetochore | 16 | 4.44x10-12 | 5.98x10-9 |
| GOTERM_BP_DIRECT | GO:0007062-sister chromatid cohesion | 17 | 9.20x10-12 | 1.53x10-8 |
| GOTERM_CC_DIRECT | GO:0030496-midbody | 18 | 1.46x10-11 | 1.97x10-8 |
| GOTERM_BP_DIRECT | GO:0000082-G1/S transition of mitotic cell cycle | 16 | 9.34x10-11 | 1.55x10-7 |
| GOTERM_CC_DIRECT | GO:0000775-chromosome, centromeric region | 12 | 9.48x10-10 | 1.28x10-6 |
| GOTERM_MF_DIRECT | GO:0005515-protein binding | 189 | 5.91x10-9 | 8.35x10-6 |
| GOTERM_BP_DIRECT | GO:0000281-mitotic cytokinesis | 9 | 1.37x10-8 | 2.28x10-5 |
| GOTERM_CC_DIRECT | GO:0000776-kinetochore | 12 | 4.49x10-8 | 6.04x10-5 |
FDR, false discovery rate; GO, gene ontology; CC, cellular component; BP, biological process; MF, molecular function.