Table 2.
Absorption kinetics for whole blood iMg2+ and serum total magnesium concentrations and urinary magnesium content.
| Parameter | Placebo | MgCl2 | p Value |
|---|---|---|---|
| iMg2+ (n = 14) | |||
| Baseline (mg/dL) | 1.25 ± 0.08 | 1.26 ± 0.01 | 0.242 |
| AUC (mg/dL•24h) | 0.84 ± 0.82 | 1.51 ± 0.96 | 0.029 |
| Cmax (mg/dL) | 1.32 ± 0.07 | 1.38 ± 0.13 | 0.034 |
| Tmax (h) | 9.54 ± 9.85 | 10.36 ± 9.30 | 0.396 |
| Serum magnesium (n = 17) | |||
| Baseline (mg/dL) | 1.95 (1.78–3.30) | 2.08 (1.76–3.19) | 0.491 |
| AUC (mg/dL•24h) | 14.55 (0–91.18) | 27.00 (0–172.93) | 0.097 |
| Cmax (mg/dL) | 2.24 (1.98–4.31) | 2.38 (1.97–4.01) | 0.221 |
| Tmax (h) | 11.38 ± 9.93 | 10.82 ± 9.11 | 0.396 |
| Urine magnesium (n = 12) | |||
| Baseline (mg) | 2.90 (0.81–47.15) | 2.95 (0.35–88.63) | 0.267 |
| AUC (mg•24h) | 139.30 ± 92.84 | 201.74 ± 161.63 | 0.118 |
| Cmax (mg) | 24.38 (13.51–81.51) | 26.12 (12.91–88.63) | 0.469 |
| Tmax (h) | 24.00 (0–24.00) | 24.00 (0–24.00) | 0.363 |
Whole blood concentration of iMg2+, concentration of total magnesium in serum, and total content of magnesium in urine collected during 24 h of MgCl2 versus placebo administration are shown. Values are given as the mean ± SD or the median (range) depending on the normality of the data. AUC = the area under the curve, Cmax = maximum (or peak) concentration, and Tmax = time (in hours) at which Cmax is observed. One-sided p values are shown.