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. 2020 May 8;20(1):550–560. doi: 10.3892/etm.2020.8733

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Copyright: © Geng et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Effect of rosuvastatin on ox-LDL-induced HUVECs apoptosis. (A) Detection of apoptosis rate by flow cytometry. (B) The values of apoptosis rate analysis were expressed as the mean ± standard deviation. (C) Effects of rosuvastatin on the mRNA levels of CHOP, sXBP1, caspase-12 in HUVECs induced by ox-LDL. The fold of mRNA levels compared with control or ox-LDL group expressed as the mean ± standard deviation. (D) Effects of rosuvastatin on the activity of caspase-12 in HUVECs induced by ox-LDL. The fold of caspase-12 activity compared with control or ox-LDL group expressed as the mean ± standard deviation. ^**P<0.01 vs. control group; ^#P<0.05 vs. ox-LDL group; ^##P<0.01 vs. ox-LDL group. ox-LDL, oxidized low-density lipoprotein; HUVECs, human umbilical vascular endothelial cells.