Table 3.

Multivariate analyses of associations of VFA, SFA, and SMM with HRQoL scales.

	Baseline (Prior to Surgery)			6 Months Post-Surgery			12 Months Post-Surgery
	VFA	SFA	SMM	VFA	SFA	SMM	VFA	SFA	SMM
Global health/QoL
β	0.005	−0.02	−0.19	−0.03	0.01	−0.03	−0.01	0.003	−0.02
p-value	0.84	0.47	0.5	0.23	0.45	0.89	0.72	0.85	0.93
Physical functioning
β	−0.02	0.02	0.18	−0.03	0.001	0.18	−0.02	0.01	−0.05
p-value	0.49	0.32	0.44	0.17	0.95	0.41	0.17	0.28	0.75
Role functioning
β	−0.005	−0.005	−0.27	−0.04	0.02	0.1	−0.02	0.005	−0.4
p-value	0.89	0.87	0.47	0.29	0.55	0.77	0.48	0.83	0.18
Social functioning
β	0.04	0.02	0.12	−0.08	0.02	−0.33	0.002	−0.03	−0.19
p-value	0.26	0.56	0.72	0.01	0.45	0.29	0.95	0.26	0.51
Fatigue
β	0.02	−0.02	−0.15	0.05	−0.01	−0.01	0.02	−0.02	−0.02
p-value	0.56	0.44	0.64	0.09	0.56	0.97	0.31	0.32	0.92
Pain
β	−0.03	−0.02	−0.32	0.06	−0.002	−0.39	0.07	0.02	1.03
p-value	0.37	0.42	0.37	0.04	0.92	0.2	0.01	0.42	0.0006

Multivariate analysis using linear regression models. Italics indicate statistically significant associations between CT-based body composition parameters and HRQoL scales. For baseline analyses, models were adjusted for age, gender, tumor stage, tumor site and neoadjuvant treatment. For six-month follow-up analyses, models were adjusted for age, gender, tumor stage, tumor site, adjuvant treatment and baseline HRQoL scores. For twelve-month follow-up analyses, models were adjusted for age, gender, tumor stage, tumor site, adjuvant treatment, and baseline and six-month HRQoL scores. Health-related quality of life (HRQoL), quality of life (QoL), visceral fat area (VFA), subcutaneous fat area (SFA), skeletal muscle mass (SMM), estimate (β).